Fructus Bruceae


Fruit of Brucea javanica (L) Merr., family Simamubaceae.

Drupe ovate, 0.5 cm in diameter; surface brown-black, with elevated net grains and irregular multangular net holes, obvious angular line seen on both sides; with scars of fruit stalk on the base. Bitter in taste, cold in nature, slightly toxic, and attributive to large intestine and liver channels.

1. Clear away heat and toxic material, kill parasites and relieve dysentery: For acute and chronic dysentery. Recently, commonly used for amebic dysentery, also for malaria and trichomonas enteritis.
2. Erode warts: External use for corn and common warts (care should be taken to protect the surrounding skin).
3. Anticarcinogenic: Topical use of its oil for papilloma of external audi-tory meatus and larynx, and skin cancer; local injection for cancer of cervix, and mammary cancer; intramuscular injection for tumor of the digestive tract, cancer of cervix and lung.

Pharmacological Action
1. Amebacidal and antiplasmodiaL
2. Bruceoside A and B, Bruceine C and Brusatol are active components which can inhibit leukemia388.
3. Irritating gastrointestinal tract and causing nausea, vomiting or abdominal pain.
4. Acute poisoning leads to slowing of respiration, acceleration of heart rate and paralysis of extremities; chronic poisoning may result in liver and kidney damage.

Administration Powder
(in capsule or coated by Arillus Longan): 1.5-2.0g tid.
10% oleum ampoule: 2-4 ml IM or topical injection once daily.
Enema: 20 pieces of fruit pounded and soaked in 1% sodium bicarbonate solution for 2 hours, used as retention enema daily for trichomonas enteritis and amebic dysentery.

The drug is erosive and toxic, and the powder should be taken with coating and after meals. Cases with peptic ulcer, gastritis, poor liver function and kidney function are contraindicated.


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Mr. Wang Tao

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